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among the abnormalities that Dr. Alois Alzheimer saw in the brain of Auguste D., although he called them different names.. In the final stages of the plaques and tangles have taken care of the thinking part of the brain and are moving into muscle control and beyond,. All these brains possessed plaques and tangles -- hallmarks of Alzheimer's disease -- beyond what would be expected in normal aging, yet shy of full. Alzheimer's Home > Alzheimer's Shows A - Z : Information. the only definite way to diagnose AD is to find out whether there are plaques and tangles in brain

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